world.sniff/sniff-mcp
world.sniff/sniff-mcp · v1.1.0 · MCP 2025-11-25
Canine genomics for agents: breed allele frequencies, AI pathogenicity + OMIA clinical disease layer
Reachability
reachable
checked 2026-07-14 04:33 UTC
Registry status active
Tools pinned 18
8b4720147388
Tools last changed
unchanged since first capture 2026-07-14
Provenance
Registry namespace world.sniff
(domain verified by the official registry)
Repository
github.com/sniffscore/sniff-mcp
Website
https://sniff.world
Remote endpoints
https://mcp.sniff.world/mcp/ (streamable-http)
Observed changes
| When (UTC) | Event | Detail |
|---|---|---|
| 2026-07-14 03:26 | first capture | 18 tools pinned |
Pinned tool definitions (18)
| Tool | Description |
|---|---|
| ask | Ask Sniff a natural-language canine-genetics question and get a GROUNDED, CITED answer (or an honest abstain). Covers inherited diseases (OMIA) and their human homologs (the dog<->human disease bridge), breed disease/carrier risk,... |
| ask_the_graph | THE INSTRUMENT — ask a free-form CROSS-SPECIES genetics question and get FILTERED, HONEST HINTS (never a confident guess). It compiles your question into a typed query plan over the dog<->human edge-graph, runs it deterministically, and... |
| disease_bridge | The fused OMIA disease layer as cited atoms. Give a `disease` (name or 'OMIA:001870-9615') for its genes, inheritance, human homolog (OMIM/Mondo bridge), and variant pathogenicity grade (AVCG, ACMG/AMP 5-tier, curated in OMIA) when... |
| ask_variant_context | THE headline query. Given a CanFam4 position (e.g. '5:56189113'), return the variant's global + popmax frequency, breed-stratified cross-breed frequencies, ESM2/Pangolin/phyloP pathogenicity, gene context, linked diseases (v1.1),... |
| variant_lookup | Single-variant lookup by CanFam4 position: ref/alt, global + popmax AF, consequence, gene, ESM2/Pangolin/phyloP, deleteriousness tier, canonical URL, provenance. |
| breed_variant_frequency | Breed-stratified allele frequency. Give a breed (e.g. 'bernese_mountain_dog') plus either a variant position or a gene symbol. Returns AF (+ rank) for the variant, or per-variant AFs in the gene. |
| gene_summary | Variants in a gene (by gene symbol), ranked by impact then ESM2 damage. Paginated (limit, default 25); returns total_variants. Use af_min to filter by global AF. |
| breed_summary | Breed profile: top damaging common variants (ESM2<=-5 & breed AF>=5%), n_dogs, breed group. Descriptive only — not a health ranking. |
| variant_search | Filtered discovery over all 9.67M variants. Predicates (combine freely): esm_max (ESM2 LLR <=), phylop_min (phyloP >=), popmax_min (popmax AF >=), gene_in (list of gene symbols), consequence, impact (HIGH/MODERATE/LOW/MODIFIER). Returns... |
| nearest_breeds | Genetically nearest breeds to the given breed (top-10-PC Euclidean in canine genetic space). Answers 'what breeds are most genetically similar to X?' via the PCA-256 breed co-embedding. |
| breed_similarity | Genetic distance between two breeds (top-10-PC Euclidean). Lower = more genetically similar. |
| semantic_search | Faceted hybrid + semantic-ranker search over the whole knowledge base (diseases, breeds, Scout discoveries). Use for fuzzy/thematic intent ('drug sensitivity in herding dogs', 'breeds prone to eye disease', 'genetically diverse... |
| disease_links | A canine inherited disease (name or OMIA id) -> its governed OMIA clinical record: mode of inheritance, causal gene(s), curated description (summary / clinical features / molecular genetics / pathology / prevalence), clinical signs as... |
| disease_lookup | Look up a canine inherited disease by name or OMIA id -> its governed OMIA clinical record (inheritance, causal gene(s), curated description, clinical signs, human OMIM analog + Mondo id, evidence base). Sourced to OMIA (CC-BY); returns... |
| search_diseases | Search the canine disease catalogue by free text -> ranked candidates [{omia_id, disease, url, score}]. Use before disease_lookup when the exact name is unknown. Dog-only. |
| breeds_in_atlas | List all 188 breeds with breed-stratified frequencies in the atlas. |
| genes_indexed | Top genes by number of variants in the atlas (discovery aid). |
| metadata | Atlas metadata: release, DOI, assembly, variant/breed counts, scope banner, and the RPC catalog. |
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